| Date | Home | Away | Result |
|---|---|---|---|
| 9/19/25 1:30 PM | Deportivo La Coruna | SD Huesca | 4-0 |
| 9/20/25 9:15 AM | CyD Leonesa | CD Castellon | 1-3 |
| 9/20/25 11:30 AM | CD Leganes | UD Las Palmas | 0-1 |
| 9/20/25 11:30 AM | Andorra CF | CD Mirandes | 1-1 |
| 9/20/25 2:00 PM | UD Almeria | Sporting Gijon | 2-1 |
| 9/21/25 7:00 AM | AD Ceuta FC | Real Saragossa | 1-0 |
| 9/21/25 9:15 AM | Albacete Balompie | Real Valladolid | 2-0 |
| 9/21/25 11:30 AM | FC Malaga | FC Cadiz | 0-1 |
| 9/21/25 11:30 AM | SD Eibar | Real Sociedad B | 2-1 |
| 9/21/25 2:00 PM | Cordoba CF | Racing Santander | 2-2 |
| 9/22/25 1:30 PM | Burgos CF | FC Granada | 1-1 |